Using Core-Shell Technology To Improve HPLC Methods Within USP: Part 4

US and Euro Pharmacopeia

Part IV: More about the Chromatographic Impact of Making Adjustments to Existing Methods Guest Author: Jeff Layne, Ph.D. Welcome to the fourth part of the series that is examining the effects Continue Reading

Using Core-Shell Technology to Improve HPLC Methods Within USP: Part 3

US and Euro Pharmacopeia

Part III.  Chromatographic Impact of Making Adjustments to Existing Isocratic Methods Guest Author: Jeff Layne, Ph.D. Welcome back to the third article of my series “Using Core-Shell Technology to Improve Continue Reading

Using Core-Shell Technology to Improve HPLC Methods within USP: Part 2

US and Euro Pharmacopeia

Harnessing the Power of Core-Shell Technology to Improve Older, Validated HPLC Methods within Acceptable European Pharmacopeia Guidelines. Guest Author: Dr. Jeff Layne Welcome back to the second article on harnessing Continue Reading

Using Core-Shell Technology to Improve HPLC Methods within USP: Part 1

U.S. Pharmacopeia

Harnessing the Power of Core-Shell Technology to Improve Older, Validated HPLC Methods Within Acceptable USP Guidelines Part One: Quality Control Methods Guest Author: Dr. Jeff Layne Hello everyone, I hope Continue Reading

Improve Performance of Strongly Basic Molecules

Guest Author: Dr. Jeff Layne One of the biggest challenges in reversed phase chromatography has always been maintaining acceptable peak shape for strongly basic analytes.  With typical silica-based reversed phase Continue Reading

The Effects of Changing Column Inner Diameter on LC-MS Applications-Part 4

Part 4: Putting Our Interpretation to the Test Guest Author: Dr. Jeff Layne Welcome back to our final installation of this blog series on the effect of column inner diameter Continue Reading

Complementary Selectivity for Peptide Analysis

Guest Author: Dr. Jeff Layne It seems like more and more companies are shifting their focus towards the development of biopharmaceuticals these days.  Peptide analysis, whether it be intact therapeutic Continue Reading

The Effects of Changing Column Inner Diameter on LC-MS Applications-Part 3

Part 3: What is the Best Column ID for You? Hi, and welcome back to the third installation of this article series on the effect of changing column inner diameter (ID) Continue Reading

Can an UHPLC Column Have Too Much Efficiency?

Is 100% aqueous stability and unique polar selectivity not enough to convince you to try Luna Omega? Well, here is another equally-compelling reason Guest Author: Dr. Jeff Layne You Can Continue Reading