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Troubleshooting GC Column Problems

 Although we wish our GC column would always perform perfectly, there are times when issues rear their ugly heads. When this happens, it can be difficult to know what the

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Ten Most Common GC Troubleshooting Questions

1. GC troubleshooting can be daunting and time-consuming so, when facing peak and resolution issues, where is the best place to start? The inlet is the most common place where

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Could Hand Sanitizer Constitute a Health Hazard?

Since July of 2020, the FDA has issued more than 100 voluntary recalls for hand sanitizers due to the presence of toxic components or deficient alcohol levels to be effective.

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Derivatizing Reagents for GC – The Buffers Strike Back

Our previous technical tip spoke about silylation reagents that may be used to derivatize a range of polar, acidic, and basic analytes to improve volatility and peak shape during gas chromatography. Silylating

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Derivatization in Gas Chromatography (GC) Explained

Gas Chromatography is a fantastic technique to achieve exceedingly sharp peaks and resolutions within a complex mixture of analytes. But each analyte must be volatile to facilitate GC analysis. Derivatization

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Nitrogen for Fast GC Analysis? Let’s Narrow Down this Idea

Guest Author - Zachary Woodward, Technical Specialist – Phenomenex USA Shorter run-times, sharper peaks, improved resolution, and low costs of carrier gas…we want it all!  These goals can seem at

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EnvironmentalFeatured

PFAS Analysis Workflow: Are you ready to take on UCMR 5 demand?

July 28, 2022July 28, 2022 Science UnfilteredLeave a comment Share

Every five years, the Safe Drinking Water Act (SDWA) requires EPA to issue a list of priority unregulated contaminants to be monitored by certain public water systems serving between 3,300 Continue Reading

Tagged Chromatography,pfas
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Monitoring Human Exposure to PFAS

July 12, 2022July 14, 2022 Science UnfilteredLeave a comment Share

Introduction As the PFAS story continues, it is becoming widely recognized that drinking water isnot the only source by which humans can be exposed and suffer the effects of harmful Continue Reading

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All About Performing GC Column Bake Outs

June 28, 2022July 19, 2022 Science UnfilteredLeave a comment Share

It is very important for GC users to know how to preserve the GC columns. Proper preservation not only helps in ensuring accurate results, but it also saves you money Continue Reading

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Choosing the Right HPLC Column for LC-MS

June 16, 2022June 16, 2022 Science UnfilteredLeave a comment Share

Mass spectrometry (MS) is one of the most popular detection techniques for liquid chromatography (LC). It is also a technique that is not compatible with many of the mobile phase Continue Reading

Tagged column phase,HPLC Column,hplc column stationary phase,lcms columns,reverse phase column,volatile buffer
FeaturedGas Chromatography (GC)

Troubleshooting GC Column Problems

June 2, 2022June 2, 2022 Science UnfilteredLeave a comment Share

 Although we wish our GC column would always perform perfectly, there are times when issues rear their ugly heads. When this happens, it can be difficult to know what the Continue Reading

FeaturedLiquid Chromatography (LC)Pharma / BiopharmaSample PreparationSitting With Scientists

Chiral SMB Perspectives with Dr. Olivier Dapremont

May 18, 2022May 17, 2022 Science UnfilteredLeave a comment Share

New look at Chiral SMB with Dr. Olivier Dapremont Olivier Dapremont earned his Ph.D. in chemical engineering and applied chemistry from the University of Pierre & Marie Curie in Paris Continue Reading

Tagged Chemical engineering,Chiral,chiral chemistry,Chiral SMB,PhenoPrep
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Chromatography Spotlight: Select the Right Mobile Phase Solvent for Reversed Phase LC

May 5, 2022April 11, 2022 Science UnfilteredLeave a comment Share

The mobile phase used for reversed phase LC can be a pure solvent, a combination of a mixed solvent, or a solvent that contains buffers and additives. The mobile phase Continue Reading

Tagged HPLC Column,hplc mobile phase,lcms mobile phase,mobile phase solvent
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Stay Prepped: Sample Preparation Best Practices

April 21, 2022April 11, 2022 Science UnfilteredLeave a comment Share

Sample preparation may feel like a basic, routine task, but it lies at the core of your HPLC analyses. Running robust, accurate, and good analytical methods for HPLC and GC Continue Reading

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GC Solutions for Testing Organic Pollutants

April 7, 2022March 8, 2022 Science UnfilteredLeave a comment Share

Modern regulations emphasize analytical methods that can separate critical analyte pairs for identification and quantitation. To meet experimental separation goals and exceed regulatory requirements, new gas chromatography (GC) column selectivities Continue Reading

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Proper Ways to Clean Your HPLC Column

March 24, 2022March 21, 2022 Science UnfilteredLeave a comment Share

We all know that HPLC columns have a finite lifetime and even after good clean-up and storage they will reach the end of their lifetime. However, there are certain measures Continue Reading

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