A Comparison of Various Core-Shell C18 Phases for Method Development

When performing reversed phase LC separations, there is a natural tendency of method developers to reach for the most commonly used phase—a C18. However, there are so many different variations of C18 phases available to method developers that it often becomes difficult to choose a C18 column that one had Continue Reading

The Effects of Changing Column Inner Diameter on LC-MS Applications- Part 2

Part 2: Changing Column Inner Diameter with Constant Flow Rate Guest Author: Dr. Jeff Layne Welcome back to this article series on the effects of changing column inner diameter on LC-MS applications. Well, let’s be fair, we are using LC-MS to illustrate our discussion, but the concepts we cover apply Continue Reading

Beta-Glucuronidase Removal: Urine the Right Place

Whether it be for a job interview or medical diagnosis, most of us have found ourselves in the vulnerable position of peeing into a cup. And though it may feel invasive or embarrassing, urine tests are remarkably helpful to doctors, courts, and hiring managers alike.

Technical Tip: Principle HPLC Conditions for LC/MS

High-performance (or pressure) liquid chromatography, more commonly known as HPLC, can be a useful tool to assist in the improvement or simplicity of mass spectral detection and analysis.

Technical Tip: Optimizing Wash and Elution Protocols in SPE Method Development

Scientists aren’t perfect. Nobody is. In our Technical Tips, we can solve your most debilitating issues—from mechanics to methodology—together.