HILIC Technical Tip for Stronger Analytical Methods

HILIC Technical Tip

Technical Tip: Engineering successful analytical methods using HILIC as an alternative retention mechanism Overview: This technical tip will outline hydrophilic interaction chromatography (or hydrophilic interaction liquid chromatography, HILIC) as an alternative retention mechanism that is particularly effective for LC-MS. Continue Reading

Resolution Fundamentals: Review for All Skill-Level Chromatographers

resolution fundamentals for chromatographers of all skill levels

Guest Author – Zachary Woodward, Technical Specialist We recently reviewed How Phase Ratio Can Shorten Run-Times While Preserving Resolution, and I would like to elaborate on the relevance of the Continue Reading

10 Questions You’ve Always Wanted to Ask About LC

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Poor Sample Recovery? You May Be Over-Drying

For most reversed-phase solid phase extraction applications using a silica-based SPE media, cartridges are initially conditioned using an organic solvent such as methanol, followed by rinsing with water or a buffer.

Technical Tip: Fronting Peaks

Scientists aren’t perfect. Nobody is. In our Technical Tips, we can solve your most debilitating issues—from mechanics to methodology—together.

Technical Tip: Ion-Pairing Agents

ion exchange sites

Scientists aren’t perfect. Nobody is. In our Technical Tips, we can solve your most debilitating issues—from mechanics to methodology—together.

Ghost Peaks Technical Tip: (BOO!) How to Spot Them & Scare Them Away

ghost peaks technical tip

  Peaks in your chromatogram not attributed to the sample injected are commonly referred to as ghost peaks. Several problems can be the cause of ghost peaks manifesting, including: Late Continue Reading