Is Your LC Column for Biologics Analysis, Truly Bio-Inert?

Let’s talk about column priming and how to address this common concern Guest Author: Chad Eichman, Ph.D., Biopharmaceutical Industry Manager With the emerging trend of biotherapeutics in the pharmaceutical industry, Continue Reading

Large vs Small Organic Molecules in Biopharmaceuticals

Biopharmaceuticals

Biopharmaceuticals have emerged as the next-gen of therapeutic (large and small) molecules in the pharmaceutical industry Guest Author: Chad Eichman, Ph.D., Biopharmaceutical Industry Manager The pharmaceutical industry has a long-standing Continue Reading

SEC Method Optimization using the Ph. Eur. for Insulin Fibrils

Insulin is a peptide hormone which plays a significant role in metabolism. In its monomer form, insulin can partially misfold, causing a cascade of non-native cross assembly of beta-pleated sheets Continue Reading

Doing HPLC Method Development for Monoclonal Antibody Aggregates? Wait a “SEC”!

By Guest Author: Brian Rivera Contrary to popular belief, size exclusion chromatography (SEC) isn’t straightforward. However, it should be—it’s a non-absorptive separation, right? Just look up an SEC column’s calibration Continue Reading

Transform Your HPLC and UHPLC Method Development Mindset on Analyzing Proteins— Including Monoclonal Antibodies!

Method development and analyzing proteins

A discussion of wide-pore/core-shell technology for monoclonal antibodies, method development considerations with wide-pore/core-shell columns, size exclusion chromatography (SEC) using sub-2 μm particles, and method optimization for SEC. (Webinar sneak peek) Continue Reading