10 Questions You’ve Always Wanted to Ask About LC

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The Proof is in the Litter: How an Innovative Product is Saving Feline Lives

Many pet owners can tell if their furry friend is sick just by looking at them. What if there was a possible diagnosis lurking in your cat’s litter?

Poor Sample Recovery? You May Be Over-Drying

For most reversed-phase solid phase extraction applications using a silica-based SPE media, cartridges are initially conditioned using an organic solvent such as methanol, followed by rinsing with water or a buffer.

How Does Temperature Affect a Compound’s Retention Time?

compound retention

The boiling point is the temperature where liquid has enough energy that molecules transferring into the vapor phase exert a pressure that is equal to the outside pressure. This allows molecules anywhere—not just the surface—to transfer to the gas phase.

Technical Tip: Principle HPLC Conditions for LC/MS

High-performance (or pressure) liquid chromatography, more commonly known as HPLC, can be a useful tool to assist in the improvement or simplicity of mass spectral detection and analysis.