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Part 3: What is the Best Column ID for You? Hi, and welcome back to the third installation of this article series on the effect of changing column inner diameter (ID) in chromatography. So far, we have taken the test probe, 17-alpha-OH-progesterone, and run a simple linear gradient on the LC-MS Continue Reading
Part 2: Changing Column Inner Diameter with Constant Flow Rate Guest Author: Dr. Jeff Layne Welcome back to this article series on the effects of changing column inner diameter on LC-MS applications. Well, let’s be fair, we are using LC-MS to illustrate our discussion, but the concepts we cover apply Continue Reading
Part 1: Changing Column Inner Diameter While Adjusting Flow Rate Guest Author: Dr. Jeff Layne Welcome everyone! Jeff Layne here, back with another article series, and this time we are returning to our method development roots. In this new series, we are going to address the topic of column inner Continue Reading
Do you ever worry about your column’s loadability? Do you find yourself Googling, “How much am I able to load onto XYZ phase?” Ever fret over this issue so much you can’t get a wink of sleep at night? Well for preparative chromatographers, this might be the case. Column loadability Continue Reading
There are several critical characteristics to take into consideration when choosing the appropriate organic solvent to use in liquid chromatography. For example, high viscosity solvents may produce backpressures that are too high for the HPLC system used.
The Humanity in Science Award was created in 2015 to recognize outstanding developments in science that could change human lives for the better. There were many runners-up who did (and do!) amazing things for humanity. Recently, The Analytical Scientist sat down with each of them to catch up, and find out how their ventures have progressed in the last 12 months.
High-performance (or pressure) liquid chromatography, more commonly known as HPLC, can be a useful tool to assist in the improvement or simplicity of mass spectral detection and analysis.
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